Age-Related Macular Degeneration

Age-Related Macular Degeneration: PEDigree clinical trial of iSONEP

Wissenschaftspreis für Dr. Aysegül Tura Aktuell: Deutsche Ophthalmologische Gesellschaft zeichnet hochkarätige Veröffentlichungen zu neuen Therapieansätzen bei Netzhauterkrankungen aus: Wissenschaftspreis der Stiftung Auge für Dr. Aysegül Tura (Universitäts-Augenklinik Lübeck)

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Oct. 17, 2011: Nexus Trial to Study Effects of iSONEP in Wet AMD Patients Without RPE Detachment

Lpath Initiates Dosing of iSONEP in Second of Two Proof-of-Concept Trials

iSONEP ™ and ASONEP(TM) are different formulations of a first-in-class therapeutic antibody developed by Lpath's ImmuneY2(TM) drug-discovery engine. Antibodies developed via this discovery engine are designed to target bioactive signaling lipids, such as S1P, that are involved in the proliferation and spread of cancer, age-related macular degeneration (AMD), inflammatory and auto-immune disorders, and many other diseases.

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Sept. 29, 2011: PEDigree Trial to Study Effects of iSONEP in Patients With RPE Detachment

Lpath Initiates Dosing of iSONEP in First of Two Proof-of-Concept Trials

In this human proof-of-concept trial, Lpath plans to dose 32 subjects -- 16 at a lower dose and 16 at a higher dose -- that have PED secondary to wet age-related macular degeneration (wet AMD) or polypoidal choroidal vasculopathy (PCV).

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Apr 8, 2011: Lpath intiates patient enrollment in PEDigree clinical trial

Lpath intiates patient enrollment in PEDigree clinical trial

Lpath intends to start another iSONEP trial in June of this year, a Phase 2 human-proof-of-concept trial to study the efficacy and safety of iSONEP in wet AMD patients that do not have PED.

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Apr 7, 2011: Lpath Initiates Enrollment of iSONEP Phase 1b/2a Proof-of-Concept Trial

Lpath Initiates Enrollment of iSONEP Phase 1b/2a Proof-of-Concept Trial

In this Phase 1b/2a trial, Lpath plans to dose 32 subjects that have retinal pigment epithelium detachment (PED) that is secondary to wet age-related macular degeneration (wet AMD) or polypoidal choroidal vasculopathy (PCV).

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March 9, 2011: Lpath Granted Another Key U.S. Patent Related to iSONEP and ASONEP Drug Programs

Lpath Granted Another Key U.S. Patent Related to iSONEP and ASONEP Drug Programs

Lpath will soon initiate two iSONEP Phase II trials: The PEDigree Study will evaluate the safety and efficacy of iSONEP in patients with RPE Detachment (PED), for which there is no approved drug, and the Nexus Study will evaluate the safety and efficacy in wet-AMD patients without PED.

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February 22, 2011: Multiple Phase 2 Trials and Pfizer Partnership Provide Path to Profits

PEDigree Phase Ib/2a preliminary data Q4 2011 and additional Phase 2 trial data 2012

ISONEP is currently beginning Phase 1b/2a trials for the treatment of wet-form AMD. With wet macular degeneration, new blood vessels grow beneath the retina and leak blood and fluid.

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December 20, 2010: Lpath Grants Pfizer Exclusive Option for Worldwide License for iSONEP

Lpath Grants Pfizer Exclusive Option for Worldwide License for iSONEP

iSONEP is scheduled to begin a Phase 1b clinical trial in wet AMD patients with Pigment Epithelial Detachment (PED), a complication of wet AMD, in the first quarter of 2011 and a Phase 2a clinical trial in wet AMD patients in the second quarter of 2011.

Oct 26, 2009: Positive phase-1 clinical trial results for ISONEP in AMD

Positive phase-1 clinical trial results for ISONEP in AMD

Lpath, Inc. reported positive results of its single-dose Phase 1 clinical trial of iSONEP, an anti-sphingosine-1-phosphate monoclonal antibody, in neovascular age-related macular degeneration (AMD) patients.

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October 2009: iSONEP Targets SIP in AMD

Will another cancer drug prove to be effective in treating AMD?

Since Philip J. Rosenfeld, MD, PhD, of Bascom Palmer Eye Center in Miami, began using bevacizumab in patients with AMD - if not before then - the treatment of neovascular AMD and resolution of choroidal neovascularization has been linked to the development of treatments designed to prevent metastasis of cancer.

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